At least 30 people were killed and 55 injured when Israeli artillery shells landed outside a United Nations-run school in Gaza, UN officials have said.
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Palestinian medical sources say up to 600 people have been killed since the attacks began, and Mr Kraehenbuhl said much more needed to be done to protect civilians.
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About 350 people had sought refuge at the school in effort to escape the fighting between Israeli soldiers and militants on the outskirts of the refugee camp, to the east of Gaza City.
Television footage showed bodies scattered on the ground amid pools of blood.
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"Nowhere is safe for civilians here in Gaza at the moment. They are fleeing their homes and they are right to do it when you look at the casualty numbers."
"It's very, very dangerous, and even the 14,000 who have sought refuge in our schools and shelters, they are not safe either."
Mr Ging said international leaders had a responsibility to act to protect civilians.
"You cannot conduct huge military operations in such densely-populated places without killing hundreds and injuring thousands of civilians," he added.